Chad D. Foradori, PhD

Research Assitant Professor - The University of Arizona College of Medicine—Phoenix in partnership with Arizona State University

UA Office Phone: (602) 827-2163
Office: Building ABC1, Room 419
Email: Chad.Foradori@arizona.edu

Education:

Post-Doc; Colorado State University College of Veterinary Medicine and Biomedical Sciences; 2003-2008

PhD; University of Cincinnati College of Medicine; 2003

BS; Muskingum University; 1998

Research Interests:

My research focuses on the neuroendocrine control of reproduction. Specifically, what factors mediate the release of gonadotropin releasing hormone (GnRH) and the subsequent release of gonadotropins (luteinizing hormone and follicle stimulating hormone) from the anterior pituitary. GnRH regulation requires the translation of neural and hormonal inputs into a precisely regulated output to achieve normal sexual development and gonadal function. Changes in the pulsatile secretion of GnRH are critical for the regulation of events leading to ovulation, inhibition of ovulation prior to puberty and during other physiological periods of infertility. Despite the importance of GnRH neuronal activity in mammalian reproduction, little is known about the inputs controlling the coordination of GnRH neurons resulting in pulsatile and preovulatory release. The paucity of knowledge is due to the fact that GnRH neurons have a limited number of synaptic inputs and express a relatively small number of steroid receptors. One way to identify the underlying mechanisms involved in the normal control of GnRH neurons is to examine the system during periods of distress or after developmental insults. Therefore, my research examines the effects of environmental neuroendocrine disruptors on GnRH activation. In doing so, we will be better able to identify those factors essential for normal reproductive function and develop intervention strategies to protect against environmental factors that may perturb normal reproductive function.

PubMed Link:

Search PubMed for a complete listing of Dr. Foradori' publications

Selected Publications:

  1. Foradori CD, Hinds LR, Hanneman WH, Handa RJ. Effects of atrazine on GnRH neuroendocrine function after withdrawal in the adult female wistar rat (2009) Biology of Reproduction Jul 15
  2. Foradori CD, Hinds LR, Hanneman WH, Legare ME, Clay CM, Handa RJ. Atrazine inhibits pulsatile LH release without altering pituitary sensitivity to a GnRH receptor agonist in female wistar rats (2009) Biology of Reproduction Jul;81(1):40-5
  3. Magee C, Foradori CD, Bruemmer JE, Arreguin-Arevalo JA, McCue PM, Handa RJ, Squires EL, Clay CM. Biological and anatomical evidence for kisspeptin regulation of the hypothalamic-pituitary-gonadal axis of estrous horse mares (2009) Endocrinology June;150(6):2813-21
  4. Foradori CD and Handa RJ. Living or dying in three quarter time: Neonatal orchestration of hippocampal cell death pathways by androgens and excitatory GABA (2008) Experimental Neurobiology May 11
  5. Dooley GP, Reardon KF, Prenni JE, Foradori CD, Legare ME, Tessari JE, Hanneman WH. Proteomic analysis of diaminochlorotriazine (DACT) adducts in wistar rat pituitary glands and LβT2 rat pituitary cells (2008). Chem Res Toxicol. Mar 28
  6. Foradori CD, Weiser MJ, Handa RJ. Non-genomic actions of androgens (2008). Frontiers in Neuroendocrinology. May;29(2):169-81.
  7. Weiser, M.J., Foradori, CD, Handa, R.J. 2007 Estrogen receptor beta in the brain: from form to function (2008). Special Issue: Steroids and the Nervous System, Brain Research Reviews. Mar;57(2):309-20
  8. Foradori CD, Werner SB, Sandau US, Clapp TR, Handa RJ. Activation of the androgen receptor alters the intracellular calcium response to glutamate in primary hippocampal neurons and modulates SERCA2 transcription (2007). Neuroscience. Oct; 12 (149):155-164
  9. Foradori CD, Lund TD, Nagahara AH, Koenig JI, Handa RJ. Corticotropin releasing hormone heteronuclear RNA and immunoreactivity are induced in novel brain sites following kainate-elicited seizures and are modulated by estrogen (2007). Brain Research. Aug 20;1164:44-54
  10. Foradori CD, Amstalden M, Coolen LM, Singh S, McManus C, Handa RJ, Goodman RL, Lehman MN. Orphanin FQ: Evidence for a central role in the control of the reproductive neuroendocrine system (2007). Endocrinology Oct;148(10):4993-5001