Jui-Cheng Hsieh, PhD

Research Assistant Professor, Department of Basic Medical Sciences - The University of Arizona College of Medicine—Phoenix in partnership with Arizona State

UA Office Phone: (602) 827-2133
Office: Building ABC1, Room 320
Email: hsieh@email.arizona.edu

Education:

PhD; The University of Arizona; 1990

MS; Institute of Molecular biology, National Tsing Hua University, Taiwan; 1984

Research Interests:

  • Determine the functional roles of the hairless gene product in skin and brain
  • Molecular analyses of hairless gene mutations from alopecia patients
  • Over-expression and purification of nuclear receptors
  • Searching and identifying the novel 1,25-dihydroxyvitamin D3-regulated target genes
  • Studying the repression mechanism of vitamin D responsive genes as mediated by hairless

PubMed Link:

Search PubMed for a complete listing of Dr. Hsieh's publications

Selected Publications:

  1. Haussler, M.R., Haussler, C.A., Bartik, L., Whitfield, G.K., Hsieh, J.-C., Slater, S., and Jurutka, P.W. (2008) Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutrition Reviews 66, S98-S112.
  2. Barthel, T.K., Mathern, D.R., Whitfield, G.K., Haussler, C.A., Hopper, H.A., IV, Hsieh, J.-C., Slater, S.A., Hsieh, G., Kaczmarska, M., Jurutka, P.W., Kolek, O.I., Ghishan, F.K., and Haussler, M.R. (2007) 1,25-dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J. Steroid Biochem. Mol. Bio. 103(3-5): 381-388
  3. Hsieh, J.-C., Dang, H. T. L., Galligan, M. A., Whitfield, G. K., Haussler, C. A., Jurutka, P. W. and Haussler, M. R. (2004) Phosphorylation of human vitamin D receptor serine-182 by PKA suppresses 1,25(OH)2D3-dependent transactivation. Biochem. Biophys. Res. Commun. 324, 801-809.
  4. Hsieh, J.-C., Whitfield, G. K., Jurutka, P. W., Haussler, C. A., Thatcher, M.L., Thompson, P. D., Dang, H. T. L., Galligan, M. A., Oza, A. K. and Haussler, M. R. (2003) Two basic amino acids C-terminal of the proximal box specifiy functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid-responsive element. Endocrinology 144, 5065-5080.
  5. Hsieh, J.-C., Sisk, J. M., Jurutka, P. W., Haussler, C. A., Slater, S. A., Haussler, M. R., and Thompson, C. C. (2003) Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling. J. Biol. Chem. 278, 38665-38674.
  6. Hsieh, J.-C., Shimizu, Y., Minoshima, S., Shimizu, N., Haussler, C.A.,Jurukta, P.W. and Haussler, M.R. (1998) Novel nuclear localization signal between the two DNA-binding zinc fingers in the human vitamin D receptor. J Cell. Bioch. 70, 94-109.
  7. Hsieh, J.-C., Jurukta, P.W., Nakajima, S., Galligan, M.A., Haussler, C.A., Shimizu, Y., Shimizu, N. Whitfield, G.K. and Haussler, M.R. (1993) Phosphorylation of the human vitamin D receptor by protein kinase C: Biochemical and functional evaluation of the serine 51 recognition site. J. Biol. Chem. 268, 15118-15128.
  8. Hsieh, J.-C., Jurukta, P.W., Galligan, M.A., Terpening, C.M., Haussler, C.A., Samuels, D.S., Shimizu, Y., Shimizu, N. and Haussler, M.R. (1991) Human vitamin D receptor is selectively phosphorylated by PKC on serine 51, a residue crucial to its trans-activation function. Proc. Natl. Acad. Sci. USA 88, 9315-9319.
  9. Hsieh, J.-C., Yoo, S.-K. and Ito, J. (1990) An essential arginine residue for mediation of protein-primed DNA replication. Proc. Natl. Acad. Sci. USA 87, 8665-8669.