Education:
Jane Coffin Childs Fellow and Special Fellow, Leukemia and Lymphoma Society; Salk Institute for Biological Studies, La Jolla, California; 2001-2007
PhD; University of Tennessee, Memphis, Tennessee; 2000
MS; University of Calcutta, India; 1992
Background:
Sourav Ghosh received a Master of Science degree in Zoology from the University of Calcutta. He subsequently completed his graduate work under John V. Cox, Department of Molecular Sciences at the University of Tennessee. Sourav performed his post-doctoral training in Tony Hunter’s lab at the Salk Institute of Biological Studies, before joining the faculty in August, 2007.
Research Interests:
Our laboratory investigates signal transduction pathways. We are broadly interested in the functional characterization of signal transduction pathways during development and in diseases.
- Apical–basal polarity signaling pathway: Apical-basal polarity or asymmetry of protein distribution along the apical-basal axis within cells is a fundamental biological property. Many aspects of cell biology such as, stem cell division and differentiation, and directional cell migration rely on proper apical-basal polarity. We are interested in the signal transduction pathways that regulate cell polarity. Our research has characterized the function of a protein kinase – atypical Protein Kinase C or aPKC – in cell adhesion and apical-basal polarity in neural stem/progenitor cells during development [2]. Current research is focused on the comprehensive understanding of the role of aPKC signaling during organogenesis, and its altered function in tumorigenesis and invasion.
- TAM family of receptor tyrosine kinases: A tightly regulated inflammatory response is essential for the protection against pathogens. Notwithstanding, unchecked or overzealous inflammation can favor the development of chronic inflammatory and autoimmune diseases. Our laboratory is investigating TAM signaling components in inflammatory diseases [3].
- NF-κB signaling pathway: Another area of interest relates to NF-κB pathway and its role in clinical pathophysiology. Deregulated activity of the transcription factor NF-κB is commonly observed in many human ailments ranging from inflammation to cancers. We have demonstrated a crosstalk between TSC-mTOR and NF-κB signaling pathways and its role in the regulation of chemosensitivity [4]. We are currently investigating additional elements of the NF-κB cascade in cancer [1].
* Applications are invited for postdoctoral research associate positions in the laboratory
PubMed Link:
Search PubMed for a complete listing of Dr. Ghosh's publications
Selected Publications:
- Role of Rap1(Trf2IP) in NFκB signaling. Hsiangling Teo, Ee Tsin Wong, Arkasubhra Ghosh, Hendrick Leush, Najib Malik, Anthony Orth, Paul de Jesus, Anthony Perry, Jeffrey D. Oliver, Nhan L. Tran, Lisa J. Speiser, Enrique Saez, Pete Schultz, Sourav Ghosh, Sumit Chanda, Inder Verma and Vinay Tergaonkar, submitted
- Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors. Sourav Ghosh, Till Marquardt, Joshua P. Thaler, Nigel Carter, Shane E. Andrews, Samuel L. Pfaff and Tony Hunter [PNAS., 2008 Jan; 105 (1):335-340].
- TAM receptors are pleiotropic inhibitors of the innate immune response. Carla V. Rothlin, Sourav Ghosh, Elina Zuniga, Michael Oldstone and Greg Lemke [Cell. 2007 December 14, 131: 1124-1136]
- Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Sourav Ghosh, Vinay Tergaonkar, Carla V. Rothlin, Ricardo G. Correa, Virginie Bottero, Pradeep Bist, Inder M. Verma, and Tony Hunter [Cancer Cell. 2006 Sep; 10 (3):215-226]
- Co-expressed EphA Receptors and Ephrin-A Ligands Mediate Opposing Actions on Growth Cone Navigation from Distinct Membrane Sub-Domains. Till Marquardt, Ryuichi Shirasaki, Sourav Ghosh, Shane E. Andrews, Nigel Carter, Tony Hunter and Samuel L. Pfaff [Cell. 2005 Apr 8;121(1):127-39.]
- Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Z. Lu, Sourav Ghosh, Z. Wang and T. Hunter [Cancer Cell. 2003 Dec; 4 (6):499-515.]
- Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and nonconsensus sites by Cdc2. O.J. Shah, Sourav Ghosh and T. Hunter [J Biol Chem. 2003 May; 278 (18):16433-16442.]
- CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin. Sourav Ghosh, F.C. Dorsey and J.V. Cox [J Cell Science. 2002 Nov; 115:4107-4115].
- Dynamics of ankyrin-containing complexes in chicken embryonic erythroid cells: role of phosphorylation. Sourav Ghosh and J.V. Cox [Mol Biol Cell. 2001 Dec; 12(12):3864-3874.]
- Chicken Erythroid AE1 Anion Exchangers Associate with the Cytoskeleton During Recycling to the Golgi. Sourav Ghosh, K.H. Cox and J.V. Cox [Mol Biol Cell. 1999 Feb; 10(2):455-469.]
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